The Role of Immune Cells in Liver Regeneration

The liver is the only organ that can regenerate and regain its original tissue-to-body weight ratio within a short period of time after tissue loss. Insufficient regeneration in patients partial hepatectomy or transplantation with grafts often leads to post-hepatectomy failure small-for-size syndrome, respectively. Enhancing injury might improve outcomes increase patient survival. Liver comprises hepatocyte proliferation, hepatic progenitor cell expansion differentiation into hepatocytes. immune system intensively involved regeneration. current review provides comprehensive overview diverse roles played by cells Macrophages, neutrophils, eosinophils, basophils, mast cells, platelets, dendritic type 1 innate lymphoid B T are implicated promoting regeneration, while natural killer overactivated supposed inhibit proliferation. We also highlight predominant underlying mechanisms mediated which may contribute development novel strategies for diseases.